Hepatitis B surface antigen can be cleared spontaneously, but this possibility is relatively low. Spontaneous clearance of hepatitis B surface antigen means that patients suffering from hepatitis B, without treatment, the hepatitis B virus in the body can be cleared spontaneously, that is, the hepatitis B surface antigen in the body can be naturally negative; according to the guidelines for the prevention and treatment of hepatitis B, the percentage of hepatitis B patients who can have a natural rate of conversion is about 0.5~1.0% per year. The spontaneous clearance of hepatitis B surface antigen is considered to be caused by the negative hepatitis B e antigen, low values of hepatitis B surface antigen, low level of viral replication, and also has a certain relationship with age. Hepatitis B can cause damage to one’s health, so it is important to pay attention to prevention, and once you have hepatitis B, it is important to treat it in a timely manner.