The possible causes of periocular pain are as follows: 1. periocular pain can be considered to be caused by eye diseases, such as glaucoma or eye fatigue. 2. periocular pain can also be seen as an aura caused by migraine, and some patients with migraine aura can have eye pain as well as photophobia and tearing. 3. periocular pain can also appear in the early stages of optic neuromyelitis optica, due to inflammatory demyelination. The pain around the eyes can also be caused by inflammatory demyelination, and can be accompanied by vision loss. 4. Pain around the eyes can also be seen clinically as a result of cerebrovascular disease, especially pain in the eyes caused by vascular spasm or vascular malformation.