High anti-cyclic citrullinated peptide antibody suggests the possibility of rheumatoid arthritis. Anti-cyclic citrullinated peptide antibody is one of the autoantibodies, which has high specificity and sensitivity for the diagnosis of rheumatoid arthritis. In addition to being used for the diagnosis of rheumatoid arthritis, anti-cyclic citrullinated peptide antibody can also be used to determine the degree of bone destruction that may occur in patients, and anti-cyclic citrullinated peptide antibody-positive patients will have more serious bone destruction than negative patients. Anti-cyclic citrullinated peptide antibody should be negative under normal circumstances. Patients with high anti-cyclic citrullinated peptide antibody should complete other autoantibodies, rheumatoid factor, blood sedimentation, blood routine, X-ray and other related auxiliary tests as soon as possible in order to clarify the causes of abnormal anti-cyclic citrullinated peptide antibody test results. Patients with high anti-cyclic citrullinated peptide antibodies should go to the rheumatology and immunology department of regular hospitals for further consultation and treatment according to the doctor’s instructions.