Failure to lower low blood pressure requires an aggressive search for associated causes. Failure to lower low blood pressure is often associated with poor lifestyle, abdominal obesity, etc., and requires active weight control, as well as active search for any secondary factors leading to elevated blood pressure. For elevated diastolic blood pressure, it is often necessary to give beta-blockers, such as metoprolol tartrate tablets and bisoprolol fumarate tablets, and related treatment with angiotensin system inhibitors, such as drugs of the priligy and sartan class, which are used to antagonize the activation of the sympathetic, renin-angiotensin-aldosterone system. In patients with a high basal blood pressure level, two or more antihypertensive drugs with different mechanisms may be combined for treatment. Intractable hypertension refers to the use of three or more antihypertensive drugs, including diuretics, during antihypertensive treatment. Patients whose blood pressure remains uncontrolled need to be clarified with or without diuretics related applications and pay attention to lifestyle improvement, to maintain a healthy weight and to eliminate conditions such as abdominal obesity, which can help lower blood pressure.