The common cause of knee pain after drinking alcohol is an acute attack of gout. If the patient has a history of increased serum uric acid or a history of gout attacks, drinking alcohol can trigger an acute attack of gout. Uric acid in the blood is precipitated out of the synovial vessels of the knee into the knee cavity to form uric acid crystals, which are deposited on the synovial surface of the knee cavity and can cause severe pain and joint redness and swelling. Serum uric acid test shows high value, erythrocyte sedimentation rate and ultrasensitive C-reactive protein test are severely over normal value, if the pain is severe, you must take or inject pain relief and anti-gout drugs such as flurbiprofen injection and goutidine to quickly relieve the pain symptoms.