Soreness in the legs after drinking, common stimulation of nerve endings, circulatory disorders several reasons, as follows: a. Stimulation of nerve endings: large amounts of alcohol will cause the body to produce acetic acid, as an acidic metabolite, can stimulate the nerve endings, causing painful symptoms in the leg muscles. Second, circulatory disorders: a large amount of alcohol, the patient is in deep sleep, which may cause the leg to be pressed by other parts of the body during sleep, resulting in soreness symptoms on one side of the leg, mainly related to circulatory disorders. If a large amount of water is consumed after drinking alcohol to promote urination, it can lead to significant relief of clinical symptoms. Also avoiding pressure on the legs during sleep to prevent impaired blood circulation can prevent sore legs. Patients should try to drink less alcohol in general and avoid drinking large amounts of alcohol.