The side effects of sertraline and paroxetine depend on what is being treated. Both of these drugs are for depression, and both are in the same class, SSRIs, which are 5-hydroxytryptamine reuptake inhibitors. In terms of side effects sertraline is relatively small, but this drug also has some side effects, for example, some people eat sertraline after the stool is more dilute, dry mouth. Paroxetine also has side effects. The biggest side effect of paroxetine is that it may have an effect on the sexual function of men and women of childbearing age, especially men. There are also anticholinergic side effects, dry mouth and tight stools after using the drug. So, relatively speaking, sertraline has fewer side effects and paroxetine has more.