High direct and indirect total bilirubin is likely to be associated with hepatocellular damage. Bilirubin is mainly metabolized by the liver, and liver problems can affect the uptake, binding and excretion of bilirubin. Common diseases include hepatitis and cirrhosis, and gallbladder and pancreatic diseases can affect bilirubin. Consider a relationship with cholelithiasis, pancreatic head cancer, and obstructive jaundice. However, elevated total bilirubin may also be a physiological phenomenon, such as physiological jaundice in newborns, which usually recovers on its own within a week or so without any other uncomfortable symptoms. In addition, long-term alcohol consumption can affect liver function and elevated total bilirubin, which can be gradually recovered by stopping alcohol consumption and regulating the condition. If your total bilirubin is high, you should talk to your doctor in time, and treat it with your clinical symptoms.