The medicine is mild, with a wide safety window and good safety for long-term use. Serious adverse reactions are rare, and only individual cases causing digestive discomfort and skin rash have been reported, as follows: 1. However, the drug is not suitable for patients with yin deficiency and fire, who may suffer from dry mouth during consumption, and in severe cases may suffer from constipation and other symptoms of digestive discomfort; 2. Allergic reactions: the 12 herbs in the formula of GUIZUAN are mostly homologous drugs, which are mild and safe, but Yuan Zhi in the formula group may cause facial flushing and papular rash, which will disappear on its own after stopping the medication. Therefore, it is not advisable to use indigestible food during the consumption of GUIZUAN to avoid digestive discomfort. At the same time, patients should be diagnosed by a TCM doctor after four diagnostic examinations before taking the drug, and should strictly follow the drug instructions when taking the drug and seek medical attention when uncomfortable symptoms appear.