Proper plasma donation in healthy people is not significantly harmful to the body, because the main component of plasma is water, which accounts for more than 90% of the main components of plasma. Also, plasma contains a small amount of various ions, including potassium ions, sodium ions, chloride ions, etc., along with various clotting factors, albumin, globulin, etc. These substances are equipped with a relatively short time to get restored, so the plasma of healthy people has no obvious effect on the human body, but people with the following diseases donating plasma will have an obvious effect on the organism. 1. People with coagulation disorders who donate plasma later, the symptoms of bleeding may be further aggravated due to a further decrease in the concentration of coagulation factors, so coagulation disorders are not able to donate plasma. 2. People with decreased immunity should not donate blood plasma, because blood plasma contains various globulins, and the immunity of the body will further decrease after donating blood plasma, which will easily cause infection. Therefore, there is no effect on healthy people who donate blood, but people with coagulation disorders or reduced immunity should not donate plasma.