Plasma donation is the process of separating the whole blood donated by the donor, separating the various blood cells and then transfusing them back into the donor’s body, and then using the remaining plasma for clinical applications. The disadvantages of plasma donation are: a. If the donor has a mild coagulation disorder, the concentration of coagulation factors in the body will drop transiently after plasma donation, which may induce bleeding symptoms. This may be manifested as bleeding spots and petechiae on the skin and mucous membranes, bleeding from the nose and gums, or even blood in the urine, so people with coagulation disorders should not donate plasma. Second, after plasma donation, the concentration of immunoglobulins in the human body may drop for a short period of time, and the immune function of the human body may be mildly reduced, making it easy for infections or other diseases to occur, so people with low immunity should not donate plasma. In conclusion, plasma donation can have a mild effect on the body’s immunity and blood clotting function.