Retinoic acid cream should generally not be used all the time, as prolonged use may lead to localized skin barrier damage, while transdermal absorption of the drug is detrimental to your health. The main ingredient of retinoic acid cream is all-trans retinoic acid, which is a keratolytic drug. Currently, it can be used for the treatment of acne vulgaris, keratosis follicularis, furunculosis, psoriasis and other diseases. Since retinoic acid cream may cause symptoms of skin irritation such as burning sensation, erythema, flaking, and dryness. If long-term use of retinoic acid cream, may lead to local redness, flaking and other irritating symptoms, damage to the local skin barrier function; at the same time, long-term use of transdermal absorption of the drug, there are certain systemic adverse reactions, such as hyperlipidemia, liver function abnormalities. Therefore, long-term use of retinoic acid cream is not recommended. Patients using such drugs, need to follow the doctor’s instructions to use, do not unauthorized use of drugs. It should be noted that pregnant women, lactating women, and people who are allergic to this product are contraindicated. If the patient during the use of retinoic acid cream, the occurrence of physical symptoms, need to consult a doctor. At the same time, the treatment process need to avoid the sun, go out need to do a good job of sun protection measures.