Swollen and itchy hands may be related to acute urticaria, atopic dermatitis, eczema, frostbite and other causes. 1. Acute urticaria: related to infection or contact with allergenic substances, manifested as sudden wind, erythema and edema with itching, and in severe cases, respiratory distress or even shock. 2. Allergic dermatitis: if contact with pollen, dust and other allergenic substances, can cause abnormal immune response in the body, can cause swelling of the hands, itching and other symptoms. 3. Eczema: due to external stimuli, contact with ultraviolet light and other factors, can first appear skin erythema, on this basis, the appearance of pimples or herpes mound, can appear hand swelling, itching and other symptoms. 4. Frostbite: limited inflammatory skin damage caused by cold, mainly manifested as purple-red patches of skin, swelling, itching and so on. It is recommended that people with swollen and itchy hands go to the hospital in a timely manner to clarify the cause of the disease and standardize the treatment under the guidance of the doctor in order to avoid delaying the condition.