Acne includes pimples, papules, and pustules that rise above the surface of the skin. If it is on the eyelids, cheeks, or forehead, it is more likely to be considered as fatty grains. Fatty grains are classified as milia and sweat duct tumors. It may also be filiform warts or follicular erythema nigricans, both of which are granular lesions felt on the skin surface at the onset. The causes of such skin diseases are mostly related to hair follicle blockage, high oil secretion, genetics, environment or diet, etc. The treatment is mostly topical drugs or physical therapy. Common causes 1, acne: Mostly considered whiteheads, which are closed acne. It is usually related to androgen and sebum secretion, as well as abnormal keratinization of the sebaceous ducts of hair follicles or diet. 2. Secondary milia often appear after trauma, skin diseases or after receiving certain treatments, and some of them may be related to damaged sweat ducts. In contrast, sweat duct tumors are benign skin appendage tumors that differentiate toward the terminal sweat ducts. They tend to occur in women, and the rash often increases during pregnancy, premenstruation, or when estrogen is used, so they are mostly considered to be endocrine-related. 3. Follicular erythema nigricans: They may be genetically related or result from genetic and environmental interactions, such as vitamin A deficiency and abnormal lipid metabolism. Treatment 1, acne: topical vitamin A acid ointment can be used to help dissolve the acne contents. Peroxybenzoyl can be used when infected by bacteria, and antibiotics such as erythromycin or clindamycin can also be used. Azelaic acid can also be used, which can reduce bacteria on the skin surface, in the hair follicles and sebaceous glands; 2. Fatty grains: This disease usually does not need to be treated, and the cyst contents can be picked out with a needle or other appropriate instrument after routine local disinfection for the cornea. Topical or oral retinoic acid can also be used, or physical therapy, such as laser ablation or electrodrying methods, can be chosen. Topical retinoic acid, or chemical peeling, microwave ionization, and cryo-laser, ultra-pulse laser or fractional laser treatment can be chosen for sweat duct tumors; 3. Follicular erythema nigricans: medication usually uses retinoic acid cream, adapalene gel, and urea cream used for exfoliation, as well as salicylic acid and hydroxyacetic acid, which can improve skin roughness and skin keratinization. Physical therapy such as intense pulsed light, Q-modulated laser, pulsed dye laser and fractional laser can also be used together with medications. Precautions The use of the above medications should be done under the guidance of a doctor and patients are advised to pay attention to facial cleansing and cuticle cleaning in their daily life. Do not use heavy, greasy or irritating skin care products or cosmetics. You should also pay attention to the diet to avoid eating too sweet or spicy stimulating food, which can easily trigger or aggravate the skin lesions.