If the nose is blocked when sleeping at night, there are usually several factors as follows: first, the most common is bacterial infectious factor, if it is bacterial infection of rhinitis can take the following types of drugs, such as levofloxacin, azithromycin, cephalosporin and penicillin, etc., can relieve the symptoms of blocked nose when sleeping at night. Secondly, if the nose is blocked at night due to allergic rhinitis, anti-allergy and antihistamine drugs, such as Xetazem, Xithromax and loratadine, can be applied to relieve the clinical symptoms of blocked nose at night. Thirdly, if the nose is blocked at night due to viral infection, ribavirin, ganciclovir and cytarabine can be taken for treatment. Fourth, taking traditional Chinese medicine can also relieve the situation of nose blockage at night, such as nasal abyss and orifice particles, nasal inflammation particles. Fifth, pay attention to the nose can not be cold, need to keep warm treatment.