In neonates, fecal occult blood and 2-3 leukocytes/HPF may be associated with acute gastroenteritis infection, which is mainly treated with medications. The findings of fecal occult blood and 2-3 leukocytes/HPF by routine fecal examination in newborns may be due to acute gastrointestinal infection factors, and may be accompanied by adverse reactions in terms of nausea, vomiting, and diarrhea. If it is a bacterial infection, antibacterial drugs such as cefixime and cefdinir can be chosen according to the drug sensitivity. If non-infectious and viral infections lead to the above symptoms, the general use of antibiotic treatment is not effective, and viral infections do not have a specific drug, you can consider switching to de-lactose milk powder, while taking montelukast to protect the gastrointestinal mucosa, probiotics such as bifidobacteria and other drugs to regulate the intestinal flora, in conjunction with the treatment. It is recommended that newborns with occult blood in the stool and 2-3 leukocytes/HPF should consult a doctor promptly for active treatment. All of the above medications are recommended to be taken under the guidance of a doctor, and should not be used on their own.