Blisters on the legs are considered to be venous blood stasis and venous thrombosis caused by poor venous blood return. It is most common in patients who are bedridden for a long time, especially in severe cases of deep vein thrombosis, and also in patients with bruising and swelling of the femur, which may appear as tension blisters in the distal extremities; patients may also have swelling, pain, and numbness in the lower extremities and the circumference of both lower extremities should be more than 3 cm different; some patients are prone to platelet aggregation and secondary thrombosis due to damage to the intima of the blood vessels after trauma; there are also patients with blood Hypercoagulability, especially in bed-ridden patients and patients with malignant tumors, is also a susceptible factor for thrombosis. After diagnosis, the limb should be elevated to promote venous blood return, and anticoagulation therapy should be actively chosen, in addition to the application of drugs to improve microcirculation.