Urethral pain after urination after taking medication for three days is not good, it may be a urinary tract infection, insensitive to drugs; there may also be urinary stones, tumors and other diseases. 1. urinary system infection, insensitive to drugs: for example, urethritis cystitis and other common urinary system infectious diseases, three days of medication is not good, it is possible to take the drug is not sensitive to the drug, so the drug did not play a therapeutic role. 2. urinary stones, tumors and other diseases: for example, kidney stones, ureteral stones, bladder tumors, urethral tumors, prostate tumors and other diseases, can also lead to urinary tract pain after urination three days of taking medication is not good. Urethral pain after urination three days of medication is not good, there may be other reasons, need to go to the regular hospital in time to check, clear the cause of the disease.