Closed injections after ankle sprains generally have no effect on pregnancy, although try not to use medications during pregnancy and in preparation for pregnancy. The use of drugs during pregnancy and preparation for pregnancy has a certain effect on the fetus, is an important cause of fetal development malformation; although the closed injection is a local injection, may not have an effect on the pregnancy, but from the eugenic aspect of the consideration, it is best to take three months after the interval between the injection and then pregnant, and wait for the injection in the body to completely evaporate the better. Try not to use drugs during the preparation for pregnancy, in the three months before the preparation for pregnancy to take folic acid tablets under the guidance of a physician, in order to better prevent fetal neural tube development malformation; during the period of time to eat a light diet, appropriate physical exercise, do not smoke, do not drink, work and rest, and keep a happy mood.