The cost of immunohistochemistry depends on the location of the malignant tumor and the index of immunohistochemistry chosen, and is related to the local price level and the level of the hospital chosen. In the case of common breast cancer, for example, the price of immunohistochemistry is about 400-600 RMB, and may reach about 1000 RMB if necessary. The higher the positive rate of these two receptors, the more effective the tumor is for endocrine therapy and the better the prognosis. Generally, after radiotherapy, endocrine drugs can be used for treatment, commonly used drugs include triamcinolone and letrozole. There is also HER-2, a product of oncogene. The higher the rate of HER-2 in the cytoplasm, the higher the malignancy of the tumor. If HER-2 is more than 3+, further genetic testing is needed, that is, HIS gene testing. Patients who are positive can be considered for targeted gene therapy, commonly used drug is Herceptin, but it is very expensive. In addition, another indicator is Ki-67, which is an indicator of cell proliferation, located in the nucleus. It is closely related to the degree of differentiation, infiltration, metastasis, and prognosis of many tumors.