The cost of immunohistochemistry depends on the location of the malignant tumor and the index of immunohistochemistry chosen, and is related to the local price level and the level of the hospital chosen. In the case of common breast cancer, for example, the price of immunohistochemistry is about 400-600 RMB, and may reach 1000-3000 RMB if necessary. The indicators of immunohistochemistry used for breast cancer mainly include the following: estrogen receptor and progesterone receptor. The higher the positive rate of these two receptors, the more effective the tumor is for endocrine therapy and the better the prognosis. Generally, after radiotherapy, endocrine drugs can be used for treatment, commonly used drugs include triamcinolone and letrozole. There is also HER-2, a product of oncogene. The higher the rate of positivity in the cytoplasm, the higher the malignancy of the tumor. If HER-2 is more than 3+, further fluorescence in situ hybridization is required for genetic testing. Patients with positive HER-2 by fluorescence in situ hybridization can be considered to be given targeted therapy against HER-2 gene, commonly used drug is Herceptin, but it is very expensive. Another indicator is Ki-67, which is an indicator of cell proliferation and is located in the nucleus. The higher its positivity, the faster the tumor is growing and the more malignant it is. It is closely related to the degree of differentiation, infiltration, metastasis, and prognosis of many tumors.