Nausea and excessive clearing of saliva in the middle of the night is most often considered to be related to esophageal reflux disease, but a stress reaction cannot be ruled out. If the symptoms are severe, prompt medical attention is recommended. If nausea and excessive salivation are accompanied by abdominal pain, acid reflux, and burning sensation in the throat, it is usually a case of esophageal reflux. It is often caused by digestive system diseases such as chronic gastritis, reflux esophagitis, and bile reflux gastritis. These lesions can lead to increased acid secretion, acid reflux and bile reflux in patients with symptoms such as nausea, vomiting and increased salivation in the middle of the night. For patients in this category, after seeking medical attention, medications such as omeprazole and cimetidine can be applied under medical prescription to suppress gastric acid secretion and relieve discomfort. And pay attention to a light diet in life. When you feel the acid reflux is serious, you can also eat some baking soda cookies to relieve the discomfort. In addition, do not rule out the stimulation of special odor in the middle of the night, resulting in saliva secretion, increased saliva, clear saliva performance, and unpleasant odor can also cause nausea, vomiting, the above situation, generally remove the cause of symptoms can be gradually alleviated.