The pain of kidney stone is usually intense. If kidney stone is painful in the middle of the night, you should go to the hospital or call 120 immediately. Before reaching the hospital, you can save yourself through heat compress, pressure, medication and other methods. After arriving at the hospital, under the guidance of professional doctors, the pain can be relieved through medication, surgery, etc. 1. Hot compress: you can place hot towels, hot water bags and other items on the most painful location, which can promote blood circulation and to some extent expand the ureteropelvic pelvis, thus achieving the purpose of pain relief. At the same time, pay attention to drinking warm water in appropriate amounts to reduce the symptoms of kidney stone pain; 2, pressure: after finding the most painful point, let family members press and hold this part, which can play a certain role in relieving the pain; 3, medication: before reaching the hospital, you can take some non-steroidal anti-inflammatory drugs, such as common ibuprofen extended-release capsules, aspirin, etc. for pain relief, and you can also use some rectal suppositories, such as indomethacin suppositories, Diclofenac sodium suppositories, administered through the anus, can also play a role in relieving pain. After going to the hospital, if the pain persists, some analgesic drugs, such as dulcolax, can be injected at the doctor’s discretion. And timely surgical treatment, such as extracorporeal shock wave lithotripsy, ureteroscopic lithotripsy, percutaneous nephrolithotomy, etc.. By breaking up or removing the stone to relieve the pain. To sum up, hot compress, compression and medication can only have a temporary effect. Patients should relieve the symptoms by eliminating the stones to achieve the purpose of root cause.