Cranial repair is a routine procedure in neurosurgical clinical work. Some people ask how much does it cost to repair 6 square feet of skull. The cost of cranial repair is indeed related to the size of the cranial defect, that is, the size of the area that needs to be repaired, and also to the kind of repair material that is used. Let’s talk about cranial bone repair materials, in the history of cranial bone repair, although there have been many repair materials, such as animal bone, autogenous bone, cow horn, ivory, celluloid, methacrylic resin, acrylic, polyethylene, silicone rubber, coral, ceramics, plexiglass, bone cement and so on, but most of these due to a variety of problems and out of the stage. Currently, titanium mesh and polyetheretherketone are commonly used in clinical practice, and titanium mesh is more widely used, but the new polyetheretherketone has even better performance and should be promoted for use. Although titanium mesh as a cranial bone repair material is widely used in the clinic, and it has its own advancement compared with other materials in the past, there are still some defects and shortcomings, and various problems may occur in clinical application, such as postoperative infection and rejection, wear and tear of the scalp, which may cause scalp ulceration and exposure of the material; titanium mesh is not hard enough, and it is easy to collapse and deform by the postoperative impact; titanium mesh is more thermally conductive, and postoperative patients may be more sensitive to the external cold, and it may be difficult for patients to feel the cold. After the operation, the patient may be sensitive to the external environment of hot and cold discomfort; after the operation to affect the patient to accept CT MRI and other medical examinations; shaping effect is not ideal and so on. Polyetheretherketone is a special polymer material emerging in recent years, with its excellent performance to become the new trend of cranial bone repair materials. Polyether ether ketone, also known as PEEK, this new material in hardness, stiffness, elasticity, stability, thermal insulation, tissue compatibility, plasticity, radiation transmissibility, magnetic compatibility, etc. are comparable to the autologous cranium, can be very good to overcome the titanium mesh material may produce a variety of problems mentioned above, placed in the human body after the comfort of a high degree of protection, aesthetics and good, ideal repair results. The size of cranial defect is generally measured in centimeters, if it is 6 square centimeters, then the size of the defect is only about 3cm * 2cm, which is not very big. But if it is 6cm square, that is 6cm*6cm, then it is quite big. The area of the skull defect is an important factor affecting the cost of cranial bone repair, generally the larger the area, the cost is more expensive, and there is a positive correlation between them. If the new polyether ether ketone PEEK material is used, then the cost may be higher than titanium mesh, but the repair effect is generally much better, greatly reducing the chance of various problems and complications after surgery. The use of advanced and excellent materials as cranial bone repair materials is one aspect, in addition, the operator also needs to continue to improve and upgrade technology and material optimization design, the introduction of cosmetic plastic surgery concepts, in order to achieve the anatomical integrity, functional perfection, beautiful appearance of the organic unity.