Advanced stage colon adenocarcinoma means that metastasis to distant organs such as liver and lungs has occurred, and the general treatments include surgery, chemotherapy, comprehensive treatment and so on. 1. Surgical treatment: according to the site of tumor occurrence, radical surgery for left half colon cancer and radical surgery for right half colon cancer can be adopted, aiming at radical resection, usually endoscopic rectal adenocarcinoma resection is chosen. If the patient’s condition is serious and the body cannot tolerate radical surgery, palliative surgery is also needed for treatment. 2. Chemotherapy: it is usually an auxiliary means after surgery and an effective means to avoid recurrence due to many high-risk factors. Commonly used drugs include 5-fluorouracil, oxaliplatin, etc. Bevacizumab can also be used. Bevacizumab, pembrolizumab and other drugs can also be used. 3. Comprehensive treatment: for advanced colon cancer patients who have already developed liver and lung metastases, the treatment aims at improving life treatment. Nutritional support should be paid more attention to. Most of the patients will suffer from nutritional deficiency due to serious damage of digestive system, so they need to improve their life treatment and provide delicious and nutritious food. Psychological treatment should be done for patients with poor mood. Patients with advanced colon adenocarcinoma should follow the doctor’s prescription for treatment, and the drugs should be applied under the doctor’s guidance.