The 13-valent pneumococcal vaccine does not specify that it should be given in the left thigh, so there is no harm in giving it in the right thigh. Neonatal pneumonia is one of the leading causes of death in newborns, and Streptococcus pneumoniae is the most important pathogen of neonatal pneumonia. The thirteen-valent Streptococcus pneumoniae vaccine is the only vaccine that can prevent Streptococcus pneumoniae infections in small-month-old children. It includes thirteen common serotypes of Streptococcus pneumoniae. The thirteen-valent pneumococcal vaccine should be injected intramuscularly, and the site of vaccination is the lateral femoral muscle on the anterior lateral side of the thigh of infants. The reason for choosing to vaccinate in the lateral femoral muscle of the thigh is that there are very few nerve trunks and large blood vessels passing through the muscle, and the lateral femoral muscle is thick, and the scope of injectable range is also wider, which makes the maneuverability strong, and there are many points to choose from for the vaccine, and the vaccine is fully absorbed and has mild local reactions after the injection. Parents are reminded that after vaccination, infants should keep the vaccination site clean and dry, reduce the infant’s activity, more rest, but also closely observe the infant, if there is a fever body temperature exceeding 38.5 degrees, poor mental state, lethargy and other symptoms, we should consult a doctor in a timely manner, to give symptomatic treatment to improve the symptoms.