If tuberculosis recurs three times. It may lead to the patient’s lung infection is difficult to control, the treatment effect is poor, easy to lead to the spread of tuberculosis, abdominal cavity, bone, brain and other parts of the infection. Most patients with recurrent TB are drug-resistant, and at this time the patient is highly contagious, which can easily lead to the spread of TB and cause infections. For patients with recurrent TB, it is often necessary to use a variety of second-line antituberculosis drugs, but this will increase the economic burden on patients, and too long a period of time, too many types of drugs can easily lead to adverse reactions to the drugs. Therefore, if TB recurs three times, it indicates that the patient’s condition is more serious. If this occurs, the patient should actively communicate with his or her doctor to include a drug-resistant treatment regimen. The drug-resistant treatment regimen should include at least pyrazinamide, fluoroquinolones, amikacin, etc. The dose of the drugs depends on the patient’s body weight, and sputum culture is recommended.