The cranial bone is indispensable in the entire tissue structure of the human body, and its role is to protect the human brain tissue from external attacks. The skull is relatively hard, but some people have skull defects due to subjective or observable factors. A skull defect means that the brain tissue lacks strong protection and the consequences are unimaginable. Cranial defects are important and patients should be vigilant in treating them, and timely cranial repair surgery is very necessary to avoid further damage. There is a critical issue in doing skull repair surgery, that is, the choice of skull repair material, and it is very difficult to get the ideal result if the material is not chosen well for postoperative recovery. Cranial repair surgery is a very common surgical procedure, and the repair materials have changed several times, from bone cement, human skull and animal bone to titanium mesh. Titanium mesh has improved a lot compared to the traditional materials, but it also has various defects and problems. How many years will titanium mesh last for skull repair? This is a question that cannot be answered accurately because many clinical verifications have shown that the use of titanium mesh for skull repair is not ideal, and the material may be exposed after surgery, and many patients have developed infections and rejection reactions after surgery, which may lead to the end of the service life of titanium mesh at any time. Is there no more cranial repair material to choose from? Of course not. To further improve and enhance cranial repair surgery, we have introduced a more advanced polymer material, namely PEEK, which is an excellent material that is quite good in terms of hardness, anti-rejection and thermal insulation, comparable to autologous cranial bone, and has a low rate of post-operative rejection infection. PEEK has the unique advantage of being able to be reconstructed in three dimensions based on the patient’s cranial data, thus restoring the skull structure and providing ideal post-operative contouring results. Our peek cranioplasty has helped many patients with cranial defects to restore the integrity of their skull and restore their health.