The principle of fat grafting for wrinkle reduction is to use autologous fat as a material to fill in wrinkles. When fat grafting for wrinkle reduction, the fat particles suctioned out are thicker and commonly used to make tunnels with thicker diameter injection needles for filling. Some doctors believe that the transplanted fat tissue also secretes some cytokines that stimulate skin synthesis and rearrange collagen to smooth out wrinkles. After fat grafting and filling, the skin will become firmer and more natural, and can make forehead lines, frown lines, crow’s feet, nasolabial folds and neck lines lighter, flatten the depressions, and achieve facial rejuvenation. We know that wrinkles are related to the breakage or loss of collagen fibers in the dermis and the loss of water in the skin tissue. Fat grafting can fill in larger depressions or tissue volume loss due to fat or muscle atrophy. However, fat cannot be injected intradermally to directly flatten wrinkles. With the evolution of fat grafting, nano-fat grafting is now available. Nano-fat is extremely tiny fat particles that can be injected directly intradermally through a fine needle with hyaluronic acid to fill in atrophy in the dermis. The principle of nano-fat grafting is that it contains a large number of fat stem cells, which not only play a role in filling, but more importantly, can promote tissue regeneration and rejuvenation, improve skin quality and remove aging-induced static wrinkles, such as crow’s feet, lip wrinkles, nipple area wrinkles, and is therefore known as the “autologous hyaluronic acid”. The general public is very positive about the wrinkle removal effect of Botox, but may not be clear about its principle of wrinkle removal. As a result, it can be confusing to choose which method to use to remove wrinkles. Sometimes after facial lipofilling, the doctor may suggest some more Botox to improve the effect. At this point, the candidate may ask, “Can’t I just get rid of my wrinkles with lipofilling? Why do I need more Botox? Originally, the principle of botulinum toxin to remove wrinkles is that the injection can block the neurotransmitter release at the neuromuscular, thus blocking the nerve conduction to the muscle, the emergence of the neuromuscular functional denervation, so that the local expression muscle paralysis, skin contraction decreases, so that the wrinkles stretch, wrinkles to reduce or disappear. Therefore, botulinum toxin has an excellent effect on eliminating dynamic wrinkles. I believe that by this point, everyone will have a more intuitive understanding of wrinkle removal. The principles of fat grafting for wrinkle removal and Botox for wrinkle removal are not the same, so there is no question of who replaces whom. The main purpose of fat grafting followed by Botox is to increase the survival rate of the fat and improve the efficacy of wrinkle removal.