Skull defects are a common and increasing occurrence of many accidents in life. What are the factors that can lead to cranial defects? According to the survey, there are many factors that can lead to cranial defects, among which, trauma, surgery and cranial lesions are the most common factors. Cranial defects can cause a significant loss of facial value. It may also lead to a series of cranial defect syndrome, so remedial measures should be taken as soon as possible after cranial defect. Generally speaking, skull repair surgery is performed for patients with skull defects. When the defect area exceeds 3 cm, it not only seriously affects the patient’s aesthetics, but also can cause a variety of clinical manifestations such as headache, dizziness, emotional anxiety and depression, pulsation in the defect area, and even can induce epilepsy, which can seriously affect the patient’s normal life and work. Therefore, patients with cranial defects need early cranial repair to protect brain tissue, relieve clinical symptoms and restore patient aesthetics. At present, polyetheretherketone PEEK is an ideal material for cranial repair, comparable to human cranial bone in terms of elasticity, strength, thermal insulation, and stability, with a low rate of rejection and infection. The cost of PEEK cranial repair is determined by the size of the patient’s defect and varies from patient to patient.