The latest research breakthroughs in hypertensive nephropathy include the effectiveness of astragaloside in treating hypertensive nephropathy, and the correlation between hypertensive nephropathy and APOL1 gene mutation. 1. Effectiveness of astragaloside in treating hypertensive nephropathy: Astragaloside is one of the main active ingredients of the traditional Chinese medicine Astragalus, which has the effects of anti-oxidative stress, anti-inflammation, anti-fibrosis, etc. It has been found that astragaloside has a close relationship with the treatment of renal diseases, and also has a correlation with renal diseases, such as hypertensive nephropathy. 2. Correlation with APOL1 gene mutation: APOL1 gene mutation has a strong correlation with chronic kidney disease caused by essential hypertension, and some patients’ hypertension, although better controlled, did not delay the progress of chronic kidney disease. It is recommended that patients with hypertensive nephropathy should go to regular hospitals in time and standardize the treatment under the guidance of doctors.