There is no such thing as what kind of antihypertensive effect is the best, only the most suitable for the patient’s antihypertensive treatment, for the patient’s specific situation, drug effectiveness, tolerance, as well as the patient’s economic situation and personal wishes, a comprehensive analysis to choose the most suitable treatment for the patient. At present, the main clinical treatment is drug therapy, clinically common antihypertensive drugs have five kinds: diuretics, beta-receptor antagonists, calcium channel blockers, ACEI/ARB and vasodilator drugs. 1. Diuretics: antihypertensive drugs that can delay ventricular remodeling and reduce edema only, but electrolyte disorders patients are prohibited from using, the more commonly used drugs in the clinic are furosemide and hydrochlorothiazide. 2. β-receptor antagonist: common drugs are metoprolol and bisoprolol, this kind of drug can delay ventricular remodeling, especially suitable for patients with dilated cardiomyopathy. Bronchial asthma, stage 4 heart failure, acute heart failure patients are prohibited. 3. Calcium channel blockers: common drugs include amlodipine, especially suitable for patients with hypertrophic cardiomyopathy and dilated heart failure. 4. ACEI/ARB: Captopodium and Chlorosartan are common clinical drugs, suitable for patients with combined diabetic nephropathy, but prohibited for patients with hyperkalemia, pregnancy, renal failure and gout. 5. Vasodilator drugs: sodium nitroprusside and nitrate are common vasodilator drugs, especially suitable for patients with angina pectoris, patients with valvular disease is prohibited. To summarize, each drug has its advantages and disadvantages, according to the patient’s individual situation, comprehensive medication, the above drugs need to be used under the guidance of a professional doctor, do not self-medication.