When the urine protein is normal but the urine creatinine is high, it should also be combined with the value of the blood creatinine, if the blood creatinine is normal, then it is necessary to go to the hospital to screen for other conditions that may cause an increase in the urine creatinine, to clarify the cause of the disease. Urinary creatinine is the concentration of creatinine in the urine after it is excreted into the urine. Clinical examination of urine creatinine, most of them are measured together with the amount of urine protein, urine micro-protein creatinine ratio, can accurately and sensitively determine the amount of urine protein, is a common indicator of early diabetes mellitus or hypertensive nephropathy screening. Increased urinary creatinine is most commonly seen in diabetes, infections, meat consumption, exercise, hypothyroidism, and intake of medications (e.g., vitamin C, levodopa, etc.). If urine protein is normal but urine creatinine is high, blood creatinine level can be tested at the same time, such as normal can be temporarily excluded from renal impairment, but should also exclude the existence of the above causes of increased urine creatinine, and according to the cause of the appropriate adjustments or follow the doctor’s instructions to use drugs. When the above situation occurs, it is recommended that patients need to consult a doctor in a timely manner, under the guidance of a professional physician to improve the relevant examinations, to clarify the cause of the disease and standardize the treatment.