The treatment of endometrial thickening depends on the condition and the patient’s wishes, according to which the best treatment plan is formulated, and the treatment methods include progesterone treatment, surgery, and so on. 1. Progesterone treatment: oral or local administration of drugs such as levonorgestrel, treatment for 3 to 6 months, more than 80% of patients can return to normal. Besides, regular review should be conducted once every 6 months. If the results of two consecutive tests are negative, there can be no need for review, and patients with various clinical risk factors should be reviewed once a year after 2 consecutive negative tests. 2. Surgical treatment: For patients without fertility requirements, total hysterectomy is preferred, and bilateral adnexectomy is recommended to reduce the risk of cancer. For patients with fertility requirements, high-dose progesterone treatment is preferred, and if lesions still exist after the course of treatment, surgical treatment should be performed. If cancerous lesions are found, the uterus and adnexa should be removed immediately. If endometrial thickening is diagnosed, it is recommended to consult a doctor in time and formulate an appropriate treatment plan under the guidance of the doctor according to one’s condition and wishes.