Salbutamol and Budesonide have different drug components, different clinical effects, different side effects and different contraindications. 1. Different drug composition: Salbutamol belongs to β2 agonists, while Budesonide belongs to glucocorticoid drugs, the above two drugs are categorized as different kinds of drugs. 2. Different clinical effects: Salbutamol is a β2 agonist, which can excite the β2 receptor of the bronchial mucosa to dilate the airways, relieve airway spasm and improve the symptoms of chest tightness due to airway spasm; while Budesonide is a glucocorticoid drug, which mainly plays an anti-inflammatory effect. 3. Different side effects: Salbutamol may cause panic, hand tremor, hypokalemia and other related side effects, while Budesonide may increase the incidence of respiratory tract infections. 4. Different contraindications: the main contraindication of salbutamol is allergic to this product and other β2 agonists, such as aerosol, allergic to alcohol and Freon should also be prohibited, severe hypertension, tachycardia and other cases need to be used with caution; the main contraindication of budesonide is allergic to any component of the drug. To summarize, although salbutamol and budesonide can be used in the treatment of asthma and other diseases, but there are great differences between the two drugs, should be combined with the specific conditions, by the local doctor’s guidance and reasonable selection of drugs.