Liver palms are related to viral hepatitis and cirrhosis, and patients need to follow the doctor’s prescription of medication and surgical treatment before they can return to normal. 1. Viral hepatitis: Typical symptoms of viral hepatitis patients include fatigue, loss of appetite, itchy skin, liver palms and spider nevus. If you want the liver palms to return to normal, patients need to follow the doctor’s instructions to apply tenofovir, entecavir, tibivudine and other nucleoside analogues for treatment, but also directly apply sofosbuvir, dalatasvir and other direct antiviral drugs for treatment. For patients with severe hepatitis, artificial liver or liver transplantation is feasible when necessary. 2. Cirrhosis: Cirrhosis can also cause liver palms in some patients. Patients can apply tenofovir, entecavir and other antiviral drugs as prescribed by doctors. Patients can also apply reduced glutathione, polyene phosphatidylcholine and other drugs to protect liver cells. For patients with severe cirrhosis, liver transplantation is feasible. Cirrhosis with ascites can be treated with transjugular vein portosystemic shunt, and those with gastroesophageal vein rupture and bleeding can be treated with endoscopic injection of sclerosing agent to stop bleeding or laparoscopic selective esophagogastric truncal splenectomy. It is recommended that people with liver palms do further detailed examination, in order to clarify the cause of the disease and then follow the doctor’s instructions to use medication, do not indiscriminate use of drugs or prescription treatment.