The new coronavirus will mutate. The replication of RNA viruses depends on their own RNA polymerase, which has poor error-correcting ability. If a gene mutation occurs when the virus is replicating, the polymerase will not remove the mutated gene. In the long run, mutated genes will continue to accumulate in RNA viruses, ultimately leading to non-stop mutation of RNA viruses. In addition, the mutation of the new coronavirus is an inevitable choice for its survival. Viruses are tiny organisms with a very simple structure. They cannot survive alone, but must survive in the cells of other organisms, which determines that they must rely on the cells of their hosts in order to survive and reproduce. Humans are the host of the new coronavirus, and the mutual adaptation of the virus and the human immune system has led to the co-evolution of the two. In other words, the interaction between the virus and the host allows them to evolve and ultimately survive together.