Multi-resistance is a very serious condition in the treatment of diseases. Multi-resistance is not a disease, but an infection in which the organism is infected and the infected microorganisms are resistant to more than three classes of antibiotics at the same time, indicating that many antibiotics are ineffective or have minimal effect, such that the inflammation cannot be effectively controlled. Therefore, managing multiresistant infections is usually clinically tricky, but not incurable. In the treatment of infectious diseases caused by multi-drug resistance, it is important to formulate the treatment based on the results of their drug sensitivity, using antibiotics with high sensitivity to the microorganisms being infected and antibiotics that cover such flora, usually in combination with antibiotics and using high-grade antibiotics. Although multi-resistant is a more serious infection, most of them can be treated and cured under the care of a specialized physician.