The main side effects of Apatinib are as follows: First, there are effects on the gastrointestinal system. Patients may experience diarrhea, vomiting, abdominal pain, loss of appetite, fecal occult blood, gastrointestinal bleeding, etc. The second point is the impact on metabolism and nutrition. Patients may develop hypoproteinemia, hypokalemia, and hypophosphatemia. The third point, the impact on the blood system. Leukopenia, granulocytopenia, thrombocytopenia, decreased hemoglobin, decreased red blood cells, etc. may occur. Fourth point, it may lead to abnormal liver function and elevated total bilirubin in patients.