The first point is that if the adverse reaction of gastrointestinal perforation occurs, the drug is permanently discontinued and requires prompt clinical resuscitation treatment. The second point is that it can raise the patient’s blood pressure. If hypertensive crisis does not occur, antihypertensive drugs can be combined, and in doing so, blood pressure is generally well controlled. If hypertensive crisis occurs, the drug is permanently discontinued and requires clinical symptomatic treatment. The third point is that some patients develop proteinuria. This phenomenon usually appears about three weeks after taking the drug and can be relieved by suspending the administration of the drug or reducing the administered dose. The fourth point is abnormal liver drug enzymes. This phenomenon occurs in the second cycle of the drug, and this adverse reaction can be treated symptomatically with liver-protective drugs.