The symptoms of sore knees at night when sleeping may be due to strain on the ligaments and tendons around the knee joint from standing and walking for a long time during the day, or it may be due to cold in the knee joint, cold stagnation and poor circulation of qi and blood, or it may be due to degenerative disease of the knee joint. If you have such symptoms, you can take three kinds of medications, namely, blood plugging tablets, diclofenac sodium and glucosamine capsules. You can also have an MRI examination of the knee joint to understand the condition of the knee joint in detail and adjust the medications according to the examination results. On the basis of medication, you can do traditional treatment such as knee acupuncture and tui-na, reduce standing and walking time, take more rest, and pay attention to keeping the knee joint warm. You can go to the rehabilitation department and pain department of the local tertiary hospital for examination and treatment, and you should pay attention to it and deal with it in time so as not to delay the condition.