Propylthiouracil tablets generally have little effect on the fetus, it is recommended to standardize the use of medication, regular testing of thyroid function. Propylthiouracil passes less through the placenta than other antithyroid drugs and is the drug of choice for the treatment of combined hyperthyroidism in pregnancy. Studies in recent years have generally concluded that appropriate or small doses of propylthiouracil for patients with combined hyperthyroidism in different stages of pregnancy are not harmful to the fetus. However, care needs to be taken not to overdose, as this may adversely affect the fetus. In addition, taking propylthiouracil may cause adverse reactions such as granulocytopenia, liver damage, skin rash, etc. Therefore, blood should be checked regularly during the use of the drug. It is contraindicated in patients who are allergic to the drug, in those with severe liver function impairment, and in those with severe leukocyte deficiency. Patients with mild hyperthyroidism are recommended to use comprehensive therapy combining small doses of drugs, rest and diet, and adjust the dosage according to the patient’s condition. Regular follow-up should be done during pregnancy to monitor thyroid levels. It is recommended that patients be detected early, treated early, and medicated appropriately under the guidance of a doctor to minimize the effects of hyperthyroidism on the fetus and the pregnant woman.