There are many types of immunosuppressants and the side effects of different immunosuppressants are not exactly the same. On the whole, long-term use of immunosuppressive drugs is harmful to the human body, including bone marrow suppression, gastrointestinal reactions, induced infections and gingival hyperplasia and other side effects. 1. Bone marrow suppression: long-term use of immunosuppressive drugs will cause bone marrow suppression, resulting in a decrease in white blood cells, hemoglobin, thrombocytopenia, etc., may be infected, anemia, bleeding and other symptoms. 2. Gastrointestinal reactions: Some immunosuppressants can cause serious gastrointestinal reactions, such as nausea, vomiting, abdominal pain, diarrhea and other adverse reactions. 3. Induced infections: Long-term use of immunosuppressants can lead to decreased immunity, increasing the risk of infections occurring or aggravating existing infections. 4. Other side effects: carcinogenic, teratogenic, gingival hyperplasia, liver and kidney function damage, peripheral neuritis, osteoporosis and so on. It is recommended to follow the guidance of a professional doctor to take the medication, follow the doctor’s instructions, and take it reasonably to avoid serious adverse reactions.