Osteosarcoma is the most common primary malignant bone tumor, which usually occurs in adolescents aged 10-25 years old and poses a serious threat to their lives. Osteosarcoma is usually found in the extremities, with rapid development and short course, and early hematogenous metastasis can occur. “It is understood that the incidence of sarcoma now occupies 15-20% of childhood tumors and 1% of adult tumors. The incidence of osteosarcoma is about 2/100,000, and the malignancy is high. 85%-90% of patients have clinically undetectable micrometastases at the time of consultation, with the lung being the most common site of metastasis, accounting for about 90%.” “Due to the lack of awareness of many lay doctors and parents about osteosarcoma and the less obvious clinical symptoms in the early stage of the disease, it results in 60% of patients being in the middle and late stages when they are seen, 50% of patients have delayed their disease because they cannot get timely diagnosis and standardized treatment, and about 30% to 40% of sarcoma patients have experienced misdiagnosis and misdiagnosis and mistreatment will make the disease progress. “ Teenagers should be alert to leg pain The knee joint is the most frequent site of pain, especially in children and adolescents with high activity levels, and pain in the joint area is often attributed to sports injuries. Joint pain is not easily associated with osteosarcoma, but pain is a major symptom of osteosarcoma, especially if the pain worsens at night. “The pain caused by tumor can be easily misdiagnosed as growing pains or thought to be general sports injuries or arthritis because of the rapid growth of bones of adolescents in this period. ” “The most basic thing is to take an X-ray of the joint area, and if it is not fixed, a CT examination is needed, and it is best to find a bone and joint tumor specialist to exclude tumor.” Early detection of osteosarcoma is mainly found in the knee joint of lower limbs and is the most common primary bone tumor in adolescents, with high malignancy and rapid development. Early detection and standardized treatment is an effective way to improve the survival rate. How to achieve early detection? In the early stage of the disease, there are always some symptoms to be found: 1. Early onset of the disease, the affected limb often has irregular hidden pain and discomfort, which starts as intermittent pain around the joint, soreness, dull pain, which is effective with painkillers. Pain unrelated to movement, night pain is obvious, because pain at night is a manifestation of tumor growth; joint pain is aggravated during movement; 3. The lump keeps increasing and the symptoms become more and more aggravated; 4. The course of the disease develops very rapidly, and even aggravates every other day. The above conditions should be seen by a doctor promptly.” Principles of osteosarcoma treatment “Many parents of patients always hope to take conservative treatment and are afraid of chemotherapy, and look to TCM for treatment. TCM can only be used as an auxiliary means in the treatment of tumors, and proper application of TCM after surgery can achieve the effects of regulating qi and blood and enhancing immune function, but the effect is very limited. Relying solely on local Chinese medicine external and internal application as a wraparound means can only delay the time of treatment and eventually lead to progression of disease, lung metastasis and death.” “Chemotherapy is the most important treatment for osteosarcoma, chemotherapy drugs can kill tumor cells in the body, leading to tumor necrosis and killing micro-metastases, the purpose of chemotherapy is mainly to kill micro-metastases in the lung, chemotherapy should be systemic, it is an important way to improve the long-term survival of patients and can greatly improve the prognosis of patients. The model of preoperative chemotherapy + surgery + postoperative chemotherapy has been widely accepted.”