Syphilis is usually not treated with erythromycin, and it is recommended to follow the doctor’s instructions for medication to avoid delays. Penicillin is the first choice for the treatment of syphilis, and alternative drugs are ceftriaxone, doxycycline, tetracycline hydrochloride, and erythromycin can be used as a substitute for penicillin in pregnant women who are allergic to penicillin, but the efficacy of the treatment is poor and the rate of resistance is high, so it is recommended to strengthen the clinical and serological follow-up. Roxithromycin belongs to macrolide antibiotics, which are broad-spectrum antibiotics. According to the instructions for use of the drug, it is mainly suitable for infections caused by Streptococcus pyogenes, Mycoplasma pneumoniae, Chlamydia, and other sensitive bacteria, and it is ineffective in the treatment of syphilis, and is not routinely used in the treatment of syphilis. Syphilis may lead to multi-organ damage and even life-threatening. Therefore, once a clear diagnosis is made, it is recommended that treatment be strictly followed to avoid aggravating the condition.