Small lymphocytes are a type of white blood cell. More small lymphocytes seen in the puncture indicates that there may be inflammatory infiltration or tumor cell infiltration. A high number of small lymphocytes in the puncture tissue indicates that there may be an inflammatory lesion at the site or a tumor cell infiltration, since lymphocytes are mainly isolated from inflammatory or tumor tissue. However, the presence of small lymphocytes in the puncture tissue does not qualify the type of disease and further examination is required. In addition, there are many other diseases with more small lymphocytes in the puncture, such as small lymphocytic lymphoma, etc. It is necessary to determine the cause of the disease under the guidance of the physician through specific analysis and relevant examinations to reduce the adverse effects of the disease.