Thyroid nodules with calcification may be considered for puncture under doctor’s supervision if they are microcalcifications, pinpoint diffuse or clustered calcifications. If they are benign, they should be reviewed regularly, and if they are malignant, they need to be treated with surgery. Ultrasonography can help to identify the benign or malignant nature of thyroid nodules. The following ultrasonographic signs suggest a high possibility of malignancy: solid hypoechoic nodules; abundant blood supply in the nodules (in case of TSH normalization); irregular nodule morphology and margins, absence of halo; tiny calcifications, pinpoint calcifications or clusters of calcifications, and so on. Thyroid nodules with calcification can be considered for fine needle aspiration biopsy under the guidance of a doctor to determine the benign or malignant nature of the nodule. If the biopsy suggests benign, the nodule can be observed temporarily and the thyroid ultrasound can be checked regularly to understand the changes of the nodule; if the biopsy suggests malignant, the nodule should be surgically removed as soon as possible. It is recommended that patients with thyroid nodules with calcification should go to regular hospitals for timely consultation, complete relevant examinations, and standardize the treatment under the guidance of doctors to avoid delaying the condition or causing adverse reactions.