Congenital iris deficiency: complete absence of the iris, congenital absence of the iris is a developmental disorder of both eyes that can be associated with a variety of ocular disorders such as corneal opacity, microcornea, lens dislocation, cataract, glaucomatous macular dysplasia strabismus nystagmus, etc., involving the whole eye. Some comorbidities are present at birth, while others may be delayed until childhood or early adulthood. Some patients may have systemic abnormalities. So, how can you prevent complications associated with congenital iris deficiency? The following is a brief description of prevention methods: The degree of iris deficiency varies from partial deficiency leading to pupillary irregularity to complete iris deficiency with a progressive trend of lens clouding, while the disease is often associated with ocular diseases such as glaucoma, corneal degeneration, retinal dysplasia, microphthalmia and lens dislocation. Therefore, when treating such patients, it is important to perform a comprehensive eye examination to detect existing or possible complications, treat or prevent them while surgically treating cataract and iris defects, and select different treatment modalities according to the patient’s clinical characteristics. Individualized surgical treatment is performed as early as possible to reduce postoperative complications and to improve the patient’s visual acuity and visual quality as much as possible.