Regorafenib is mainly used for some metastatic colorectal cancer and other diseases, and the common side effects are pain, fatigue, diarrhea and so on. Regorafenib is a small molecule inhibitor of many kinases in the body, with the effect of inhibiting the growth of tumors, clinically, it is mainly used for some gastrointestinal mesenchymal tumors, metastatic colorectal cancer, and hepatocellular carcinoma patients and so on. The frequent side effects of this product include pain, hand and foot skin reactions, fatigue, diarrhea, decreased appetite, infections, etc. Serious side effects include severe liver injury and gastrointestinal perforation. It is contraindicated for those who are allergic to the ingredients in this product. It is recommended to use the drug under the guidance of a physician in accordance with the condition, if any significant discomfort occurs after the use of the drug, please consult a physician promptly.