Last Thursday, grandparents brought one-week-old Doudou (a pseudonym) to Xiamen Children’s Hospital for an eye appointment. Doudou’s grandmother told the doctor that she found that three or four months ago Doudou was always unable to grasp things, and recently found that Doudou’s eyes were a bit slanted to the outside, so she came to the hospital to look at her eyes. After a careful physical examination, the doctor found that Doudou had a white pupil in his right eye, both eyes were not catching light, and he had an exotropia. Therefore, the doctor told Doudou’s grandmother that she suspected that Doudou might have a fundus lesion because of the white pupil in her right eye, and recommended that she have a RetCam fundus exam. Doudou’s grandmother accepted the recommendation for a RetCam fundus examination. The RetCam fundus examination revealed a substantial bulging swelling in the fundus of Doudou’s right eye and an extensive retinal detachment with a spherical subretinal swelling in the fundus of his left eye. Based on the findings, the doctor suspected that the child had retinoblastoma, a highly malignant childhood tumor. Therefore, the doctor also recommended that the parents undergo an ultrasound and CT examination of the eyes to clarify the diagnosis. After the ultrasound and CT examinations, Doudou’s disease was diagnosed as retinoblastoma. Due to the late detection, the tumor had basically occupied the entire eye of Doudou, and Doudou was faced with the painful choice of having her eye removed in order to continue her life. Retinoblastoma Tips Retinoblastoma is the most common intraocular malignancy in infants and children, with about half being autosomal dominant and the other half being caused by genetic mutations. It usually develops before the age of three and has an insidious onset. Since most of the patients are infants, it is not easy for parents to detect the tumor. In early stage, small tumors can be treated with scleral condensation, dressing, laser and other conservative treatments to preserve the eye and even vision. Because retinoblastoma develops in the retina, a fundus examination with RetCam can help detect the disease early. If parents find that their baby’s eyes are not looking, not following objects, not following light, not walking to avoid obstacles, and not grasping objects, they should take their baby for an eye examination as soon as possible to avoid delaying the disease. Looking back at Doudou’s condition, if she could have had a fundus examination earlier, perhaps the prognosis would have been different. RetCam III is an objective and non-invasive fundus retinal imaging system that provides quick detection and clear images for early detection of fundus lesions in infants and children, as well as for preservation and follow-up of disease progression.